The effects of environmental interventions on basal ganglia functioning

环境干预对基底神经节功能的影响

• 批准号: 138523-2006
• 负责人: Mazurek, Michael
• 金额: $ 1.64万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2007
• 资助国家: 加拿大
• 起止时间: 2007-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=364562
• 关键词: effects; environmental; interventions; basal; ganglia

The basal ganglia are a set of brain structures that act as a feedback circuit to modify the functioning of the cerebral cortex.  Proper functioning of the basal ganglia is required for the selection and execution of programmed sequences of movements ("motor programmes").  The neurotransmitter dopamine plays a particularly crucial role in the regulation of basal ganglia function.  Factors which alter dopaminergic signaling within the basal ganglia interfere with the ability to access motor programmes and thereby impair an individual's ability to respond effectively to events in the external world.  It is known that the intrauterine environment and the early life environment can have long-term behavioural effects.  The present proposal aims to study whether these behavioural effects might be mediated, at least in part, by changes in the basal ganglia.  The proposed studies should help to clarify the neural mechanisms by which early life events are able to exert long-lasting effects on behaviour.  They should also indicate whether intrauterine exposure to antipsychotic medication may constitute a risk factor for the later development of Parkinson's disease.

基底神经节是一组大脑结构，其作为反馈回路来修改大脑皮层的功能。基底神经节的适当功能是选择和执行程序化动作序列所必需的（“机动车方案”）。神经递质多巴胺在调节基底神经节功能中起着特别关键的作用。改变基底神经节内多巴胺能信号传导的因素神经节会干扰运动程式的运作，从而削弱个人对外界事件作出有效反应的能力。众所周知，子宫内的环境及生命早期的环境会对行为造成长期影响。本建议旨在研究这些行为影响是否可由这些研究将有助于阐明早期生活事件能够对行为产生长期影响的神经机制，还将表明宫内暴露于抗精神病药物是否可能构成日后发生帕金森病的风险因素。