Detecting synergistic effects of pharmacological and non-pharmacological interventions for AD/ADRD

检测 AD/ADRD 药物和非药物干预措施的协同效应

基本信息

  • 批准号:
    10501245
  • 负责人:
  • 金额:
    $ 78.15万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-09-01 至 2027-05-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY Alzheimer's disease (AD) and related dementia (AD/ADRD) is a multifactorial and heterogeneous disorder. Most current studies focus on drug interventions for AD/ADRD and currently none of pharmacological intervention (PI) discovery research has been translated into effective treatments. However, increasing evidence demonstrates that non-pharmacological interventions (NPI), such as sleep, diet, dietary supplements, aerobic exercise, aromatherapy, light therapy, cognitive training, are potentially modifiable and thus offer alternative opportunities for AD/ADRD prevention. Thus, the objective of this project is to develop translational informatics approaches to aggregate, standardize and discover the effects of drug and NPI candidates on AD/ADRD using multi-modal data resources (i.e., biomedical literature, EHR, clinical trials) followed by animal model validation. To achieve our goal, we propose the following aims: 1) constructing a comprehensive Pharmacological And Non- Pharmacological Interventions for Alzheimer's Disease Knowledge Graph (PANIA-KG) from biomedical literature and other knowledge bases; 2) detecting, understanding, and visualization of drug repurposing signals of PIs, NPIs, and their synergistical effects for AD/ADRD using the PANIA-KG; 3) re-ranking and validating individual and synergistical drug repurposing signals using multimodal data sources and animal models. The successful completion of this project will deliver a comprehensive NPI knowledge graph, novel informatics approaches, ranked list of drug and NPI candidates, and validated synergistic intervention using multi-modal data sources. The generated approaches, PANIA-KG and ranked lists can further our clinical investigations and clinical trial design which focuses on synergistic effects of drug and NPIs for AD/ADRD.
项目总结

项目成果

期刊论文数量(0)
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会议论文数量(0)
专利数量(0)

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HUA XU其他文献

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{{ truncateString('HUA XU', 18)}}的其他基金

Leveraging Longitudinal Data and Informatics Technology to Understand the Role of Bilingualism in Cognitive Resilience, Aging and Dementia
利用纵向数据和信息学技术了解双语在认知弹性、衰老和痴呆中的作用
  • 批准号:
    10583170
  • 财政年份:
    2023
  • 资助金额:
    $ 78.15万
  • 项目类别:
Engagement and outreach to achieve a FAIR data ecosystem for the BICAN
参与和推广,为 BICAN 实现公平的数据生态系统
  • 批准号:
    10523908
  • 财政年份:
    2022
  • 资助金额:
    $ 78.15万
  • 项目类别:
Interactive machine learning methods for clinical natural language processing
用于临床自然语言处理的交互式机器学习方法
  • 批准号:
    8818096
  • 财政年份:
    2010
  • 资助金额:
    $ 78.15万
  • 项目类别:
Interactive machine learning methods for clinical natural language processing
用于临床自然语言处理的交互式机器学习方法
  • 批准号:
    9132834
  • 财政年份:
    2010
  • 资助金额:
    $ 78.15万
  • 项目类别:
Real-time Disambiguation of Abbreviations in Clinical Notes
临床记录中缩写词的实时消歧
  • 批准号:
    8077875
  • 财政年份:
    2010
  • 资助金额:
    $ 78.15万
  • 项目类别:
Real-time Disambiguation of Abbreviations in Clinical Notes
临床记录中缩写词的实时消歧
  • 批准号:
    7866149
  • 财政年份:
    2010
  • 资助金额:
    $ 78.15万
  • 项目类别:
Real-time Disambiguation of Abbreviations in Clinical Notes
临床记录中缩写词的实时消歧
  • 批准号:
    8589822
  • 财政年份:
    2010
  • 资助金额:
    $ 78.15万
  • 项目类别:
Real-time Disambiguation of Abbreviations in Clinical Notes
临床记录中缩写词的实时消歧
  • 批准号:
    8305149
  • 财政年份:
    2010
  • 资助金额:
    $ 78.15万
  • 项目类别:
An in-silico method for epidemiological studies using Electronic Medical Records
使用电子病历进行流行病学研究的计算机方法
  • 批准号:
    8110041
  • 财政年份:
    2009
  • 资助金额:
    $ 78.15万
  • 项目类别:
An in-silico method for epidemiological studies using Electronic Medical Records
使用电子病历进行流行病学研究的计算机方法
  • 批准号:
    7726747
  • 财政年份:
    2009
  • 资助金额:
    $ 78.15万
  • 项目类别:

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