Detecting synergistic effects of pharmacological and non-pharmacological interventions for AD/ADRD
检测 AD/ADRD 药物和非药物干预措施的协同效应
基本信息
- 批准号:10501245
- 负责人:
- 金额:$ 78.15万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-01 至 2027-05-31
- 项目状态:未结题
- 来源:
- 关键词:AerobicAerobic ExerciseAffectAlzheimer&aposs DiseaseAlzheimer&aposs disease related dementiaAmericanAnimal ModelAnimalsAromatherapyBrain DiseasesClinical TrialsClinical Trials DesignCognitiveCognitive agingCollaborationsCommunitiesDataData SourcesDementiaDietDiseaseElderlyElectronic Health RecordEnvironmental Risk FactorGene TargetingGenetic RiskGoalsIndividualInformaticsInterventionKnowledgeLightLinkLiteratureMethodsMiningModelingNatural Language ProcessingNetwork-basedOntologyPharmaceutical PreparationsPharmacologyPhototherapyPreventionReportingResearchSignal TransductionSiteSleepStandardizationTranslatingValidationVisualizationWorkalternative treatmentclinical investigationcognitive trainingcomputerized toolsdata resourcedietarydietary supplementsdrug discoverydrug repurposingeffective therapyimprovedin silicoin vivoinnovationintervention effectknowledge baseknowledge graphmouse modelmultimodal datamultimodalityneural networknovelontology developmentpopulation basedpredictive modelingpreventsynergismtool
项目摘要
PROJECT SUMMARY
Alzheimer's disease (AD) and related dementia (AD/ADRD) is a multifactorial and heterogeneous disorder. Most
current studies focus on drug interventions for AD/ADRD and currently none of pharmacological intervention (PI)
discovery research has been translated into effective treatments. However, increasing evidence demonstrates
that non-pharmacological interventions (NPI), such as sleep, diet, dietary supplements, aerobic exercise,
aromatherapy, light therapy, cognitive training, are potentially modifiable and thus offer alternative opportunities
for AD/ADRD prevention. Thus, the objective of this project is to develop translational informatics approaches to
aggregate, standardize and discover the effects of drug and NPI candidates on AD/ADRD using multi-modal
data resources (i.e., biomedical literature, EHR, clinical trials) followed by animal model validation. To achieve
our goal, we propose the following aims: 1) constructing a comprehensive Pharmacological And Non-
Pharmacological Interventions for Alzheimer's Disease Knowledge Graph (PANIA-KG) from biomedical literature
and other knowledge bases; 2) detecting, understanding, and visualization of drug repurposing signals of PIs,
NPIs, and their synergistical effects for AD/ADRD using the PANIA-KG; 3) re-ranking and validating individual
and synergistical drug repurposing signals using multimodal data sources and animal models. The successful
completion of this project will deliver a comprehensive NPI knowledge graph, novel informatics approaches,
ranked list of drug and NPI candidates, and validated synergistic intervention using multi-modal data sources.
The generated approaches, PANIA-KG and ranked lists can further our clinical investigations and clinical trial
design which focuses on synergistic effects of drug and NPIs for AD/ADRD.
项目摘要
阿尔茨海默病(AD)及其相关痴呆(AD/ADRD)是一种多因素异质性疾病。最
目前的研究集中在药物干预AD/ADRD,目前没有药物干预(PI)
发现性研究已经转化为有效的治疗方法。然而,越来越多的证据表明,
非药物干预(NPI),如睡眠,饮食,膳食补充剂,有氧运动,
芳香疗法,光疗法,认知训练,是潜在的修改,从而提供替代的机会
AD/ADRD预防。因此,本项目的目标是开发翻译信息学方法,
使用多模式汇总、标准化和发现药物和NPI候选物对AD/ADRD的影响
数据资源(即,生物医学文献、EHR、临床试验),然后进行动物模型验证。实现
我们的目标,我们提出了以下目标:1)构建一个全面的药理学和非药理学,
来自生物医学文献的阿尔茨海默病药物干预知识图谱(PANIA-KG)
和其他知识库; 2)检测、理解和可视化PI的药物再利用信号,
NPI及其对AD/ADRD的协同作用(使用PANIA-KG); 3)重新排序和验证个体
以及使用多模态数据源和动物模型的协同药物再利用信号。成功
该项目的完成将提供全面的NPI知识图,新颖的信息学方法,
药物和NPI候选药物的排名列表,并使用多模式数据源验证协同干预。
生成的方法、PANIA-KG和排序列表可以进一步促进我们的临床研究和临床试验
该设计关注药物和NPI对AD/ADRD的协同作用。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Interactive machine learning methods for clinical natural language processing
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- 批准号:
9132834 - 财政年份:2010
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8077875 - 财政年份:2010
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$ 78.15万 - 项目类别:
Real-time Disambiguation of Abbreviations in Clinical Notes
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Real-time Disambiguation of Abbreviations in Clinical Notes
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8589822 - 财政年份:2010
- 资助金额:
$ 78.15万 - 项目类别:
Real-time Disambiguation of Abbreviations in Clinical Notes
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- 批准号:
8305149 - 财政年份:2010
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$ 78.15万 - 项目类别:
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