Detecting synergistic effects of pharmacological and non-pharmacological interventions for AD/ADRD
检测 AD/ADRD 药物和非药物干预措施的协同效应
基本信息
- 批准号:10501245
- 负责人:
- 金额:$ 78.15万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-01 至 2027-05-31
- 项目状态:未结题
- 来源:
- 关键词:AerobicAerobic ExerciseAffectAlzheimer&aposs DiseaseAlzheimer&aposs disease related dementiaAmericanAnimal ModelAnimalsAromatherapyBrain DiseasesClinical TrialsClinical Trials DesignCognitiveCognitive agingCollaborationsCommunitiesDataData SourcesDementiaDietDiseaseElderlyElectronic Health RecordEnvironmental Risk FactorGene TargetingGenetic RiskGoalsIndividualInformaticsInterventionKnowledgeLightLinkLiteratureMethodsMiningModelingNatural Language ProcessingNetwork-basedOntologyPharmaceutical PreparationsPharmacologyPhototherapyPreventionReportingResearchSignal TransductionSiteSleepStandardizationTranslatingValidationVisualizationWorkalternative treatmentclinical investigationcognitive trainingcomputerized toolsdata resourcedietarydietary supplementsdrug discoverydrug repurposingeffective therapyimprovedin silicoin vivoinnovationintervention effectknowledge baseknowledge graphmouse modelmultimodal datamultimodalityneural networknovelontology developmentpopulation basedpredictive modelingpreventsynergismtool
项目摘要
PROJECT SUMMARY
Alzheimer's disease (AD) and related dementia (AD/ADRD) is a multifactorial and heterogeneous disorder. Most
current studies focus on drug interventions for AD/ADRD and currently none of pharmacological intervention (PI)
discovery research has been translated into effective treatments. However, increasing evidence demonstrates
that non-pharmacological interventions (NPI), such as sleep, diet, dietary supplements, aerobic exercise,
aromatherapy, light therapy, cognitive training, are potentially modifiable and thus offer alternative opportunities
for AD/ADRD prevention. Thus, the objective of this project is to develop translational informatics approaches to
aggregate, standardize and discover the effects of drug and NPI candidates on AD/ADRD using multi-modal
data resources (i.e., biomedical literature, EHR, clinical trials) followed by animal model validation. To achieve
our goal, we propose the following aims: 1) constructing a comprehensive Pharmacological And Non-
Pharmacological Interventions for Alzheimer's Disease Knowledge Graph (PANIA-KG) from biomedical literature
and other knowledge bases; 2) detecting, understanding, and visualization of drug repurposing signals of PIs,
NPIs, and their synergistical effects for AD/ADRD using the PANIA-KG; 3) re-ranking and validating individual
and synergistical drug repurposing signals using multimodal data sources and animal models. The successful
completion of this project will deliver a comprehensive NPI knowledge graph, novel informatics approaches,
ranked list of drug and NPI candidates, and validated synergistic intervention using multi-modal data sources.
The generated approaches, PANIA-KG and ranked lists can further our clinical investigations and clinical trial
design which focuses on synergistic effects of drug and NPIs for AD/ADRD.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('HUA XU', 18)}}的其他基金
Leveraging Longitudinal Data and Informatics Technology to Understand the Role of Bilingualism in Cognitive Resilience, Aging and Dementia
利用纵向数据和信息学技术了解双语在认知弹性、衰老和痴呆中的作用
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$ 78.15万 - 项目类别:
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- 资助金额:
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Interactive machine learning methods for clinical natural language processing
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- 批准号:
8818096 - 财政年份:2010
- 资助金额:
$ 78.15万 - 项目类别:
Interactive machine learning methods for clinical natural language processing
用于临床自然语言处理的交互式机器学习方法
- 批准号:
9132834 - 财政年份:2010
- 资助金额:
$ 78.15万 - 项目类别:
Real-time Disambiguation of Abbreviations in Clinical Notes
临床记录中缩写词的实时消歧
- 批准号:
8077875 - 财政年份:2010
- 资助金额:
$ 78.15万 - 项目类别:
Real-time Disambiguation of Abbreviations in Clinical Notes
临床记录中缩写词的实时消歧
- 批准号:
7866149 - 财政年份:2010
- 资助金额:
$ 78.15万 - 项目类别:
Real-time Disambiguation of Abbreviations in Clinical Notes
临床记录中缩写词的实时消歧
- 批准号:
8589822 - 财政年份:2010
- 资助金额:
$ 78.15万 - 项目类别:
Real-time Disambiguation of Abbreviations in Clinical Notes
临床记录中缩写词的实时消歧
- 批准号:
8305149 - 财政年份:2010
- 资助金额:
$ 78.15万 - 项目类别:
An in-silico method for epidemiological studies using Electronic Medical Records
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- 资助金额:
$ 78.15万 - 项目类别:
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