Regulation and function of the protein tyrosine phosphatase TCPTP in mitosis

细胞周期是细胞繁殖的普遍过程，是所有生物生长发育的基础。细胞周期中最重要的事件涉及S期染色体DNA的复制和有丝分裂时复制的DNA分离到后代细胞中。从形态上讲，有丝分裂是细胞周期中最动态的阶段，涉及到许多过程的精确协调，这些过程是由可逆的蛋白质磷酸化控制的。蛋白磷酸酶在可逆的蛋白质磷酸化过程中起着重要的作用，对有丝分裂是必不可少的。这项拨款提案的重点是了解蛋白质磷酸酶在有丝分裂中的调节和功能。我们的研究将为调节有丝分裂的过程提供新的见解，并可能导致治疗癌症的替代策略的发展。

The cell cycle is a universal process by which cells reproduce and it underlies the growth and development of all living organisms. The most important events of the cell cycle concern the replication of chromosomal DNA during S phase and the separation of replicated DNA into progeny cells at mitosis. Mitosis is morphologically the most dynamic phase of the cell cycle and involves the precise coordination of many processes that are governed by reversible protein phosphorylation. Protein phosphatases play an important role in reversible protein phosphorylation and they are essential for mitosis. This grant proposal is focused on understanding the regulation and function of protein phosphatases in mitosis. Our studies will provide novel insight into processes mediating mitosis and may lead to the development of alternative strategies for treating cancer.