Characterisation of TCPTP as a tumour suppressor

TCPTP 作为肿瘤抑制因子的表征

• 批准号: nhmrc : 606605
• 负责人: Prof Tony Tiganis
• 金额: $ 39.8万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/characterisation-tcptp-tumour-suppressor/82896
• 关键词: Characterisation; TCPTP; tumour; suppressor

Breast cancer is the most frequent malignancy among women, with an estimated 1 million new cases per year worldwide. A family of enzymes known as protein tyrosine kinases (PTKs) are fundamental in the initiation and progression of tumour growth and they are frequently hyperactivated in breast cancer. This proposal will examine whether inactivation of the enzyme known as TCPTP contributes to PTK hyperactivation and tumorigenicity in breast cancer.

乳腺癌是妇女中最常见的恶性肿瘤，估计全世界每年有100万新发病例。蛋白酪氨酸激酶（PTK）是一个酶家族，在肿瘤生长的起始和进展中起着重要作用，并且在乳腺癌中经常被过度激活。这项提案将研究是否被称为TCPTP的酶的失活有助于PTK过度激活和乳腺癌的致瘤性。