Analysis of the Role of Snapin in the Regulation of SNARE Complex Assembly

Snapin在SNARE复合体组装调控中的作用分析

• 批准号: DP0208625
• 负责人: Prof Tony Tiganis
• 金额: $ 3.07万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0208625
• 关键词: Analysis; Role; Snapin; Regulation; SNARE

The aims of the proposed studies are to investigate the role played by a protein, snapin in the trafficking of membranes and cargo proteins between different compartments inside mammalian cells. Membrane trafficking is a fundamental cellular process that requires a family of related molecules termed SNARES. We have recently discovered that snapin interacts with certain members of the SNARE family, implying a critical role in membrane trafficking. The proposed studies will provide important new insights into the molecular mechanisms underlying the function of both snapin and SNAREs, and membrane trafficking in general.

拟议的研究的目的是调查蛋白质，snapin在哺乳动物细胞内不同隔室之间的膜和货物蛋白的运输中所起的作用。膜运输是一个基本的细胞过程，需要一个家庭的相关分子称为SNARES。我们最近发现，snapin与SNARE家族的某些成员相互作用，这意味着在膜运输中的关键作用。拟议的研究将提供重要的新的见解的分子机制背后的功能的snapin和SNARE，和一般的膜运输。