REGULATION OF GLUCOCORTICOID SENSITIVITY BY ANNEXIN-1

Annexin-1 对糖皮质激素敏感性的调节

基本信息

  • 批准号:
    nhmrc : 436692
  • 负责人:
  • 金额:
    $ 35.6万
  • 依托单位:
  • 依托单位国家:
    澳大利亚
  • 项目类别:
    NHMRC Project Grants
  • 财政年份:
    2007
  • 资助国家:
    澳大利亚
  • 起止时间:
    2007-01-01 至 2009-12-31
  • 项目状态:
    已结题

项目摘要

Steroids like prednisolone or cortisone are very effective at reducing inflammation in diseases like rheumatoid arthritis and are particularly known to decrease substances involved in inflammation. Almost 70% of patients with rheumatoid arthritis are treated more or less continuously with steroids. Steroid resistance (need for higher doses) or changes in steroid-sensitivity has been widely recognized in asthma, inflammatory bowel disease, and rheumatoid arthritis. Many new drug therapies however have the aim of keeping cortisone use to a minimum because of undesirable side effects like osteoporosis. Annexin-1 is an anti-inflammatory substance important in arthritis development which is also known to mediate many of the actions of steroids. However, the possible contribution of annexin-1 to mediate the effect of steroids in the regulation of these substances has not been examined. Moreover, how annexin-1 turns genes on is not known. Our studies will therefore reveal whether the absence of annexin-1 will increase inflammatory substances turn genes, and secondly, by determining the possible substances regulated by annexin-1 if the treatment with steroids are less effective in the absence of annexin-1. If annexin-1 is found either to increase anti-inflammatory substances or to mediate the effect of therapeutic steroids, its capacity to be involved in the beneficial effect of steroids may have an important impact in treatment of arthritis and other inflammatory diseases. If annexin-1 functionally acts as steroids, the reduction or discontinuation of steroid use will be possible.
像强的松或可的松这样的类固醇在减少类风湿关节炎等疾病的炎症方面非常有效,尤其是在减少炎症相关物质方面。几乎70%的类风湿性关节炎患者或多或少地持续使用类固醇治疗。类固醇抵抗(需要更高剂量)或类固醇敏感性改变已在哮喘、炎症性肠病和类风湿性关节炎中得到广泛认可。然而,由于骨质疏松等不良副作用,许多新药物疗法的目标是将可的松的使用降至最低。膜联蛋白-1是一种抗炎物质,在关节炎的发展中很重要,它也介导了许多类固醇的作用。然而,在这些物质的调节中,膜联蛋白-1介导类固醇作用的可能贡献尚未得到检验。此外,膜联蛋白-1如何开启基因尚不清楚。因此,我们的研究将揭示缺乏膜联蛋白-1是否会增加炎症物质转化基因,其次,如果在缺乏膜联蛋白-1的情况下使用类固醇治疗效果较差,则确定由膜联蛋白-1调节的可能物质。如果发现膜联蛋白-1增加抗炎物质或介导治疗性类固醇的作用,其参与类固醇有益作用的能力可能对关节炎和其他炎症性疾病的治疗有重要影响。如果膜联蛋白-1在功能上起到类固醇的作用,减少或停止使用类固醇是可能的。

项目成果

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Dr Yuan Yang其他文献

Dr Yuan Yang的其他文献

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{{ truncateString('Dr Yuan Yang', 18)}}的其他基金

Regulation of arthritis and skin inflammation by annexin-1
annexin-1 对关节炎和皮肤炎症的调节
  • 批准号:
    nhmrc : 1008991
  • 财政年份:
    2011
  • 资助金额:
    $ 35.6万
  • 项目类别:
    NHMRC Project Grants

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  • 项目类别:
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