Regulation of arthritis and skin inflammation by annexin-1

annexin-1 对关节炎和皮肤炎症的调节

• 批准号: nhmrc : 1008991
• 负责人: Dr Yuan Yang
• 金额: $ 40.87万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-arthritis-skin-annexin-1/109364
• 关键词: Regulation; arthritis; skin; inflammation; annexin

Annexin-1, an antiinflammatory substance, mediates many of the actions of steroids. Our studies will reveal whether annexin-1 will reduce inflammatory and immune responses, and secondly, determine the substances regulated by annexin-1 in immune responses. If annexin-1 is found to mediate the immune regulatory effect of steroids, its capacity to be involved in the beneficial effect of steroids may have an important impact in treatment of arthritis and other inflammatory diseases.

膜联蛋白-1是一种抗炎物质，参与类固醇的许多作用。我们的研究将揭示膜联蛋白-1是否会减少炎症和免疫反应，其次，确定免疫反应中膜联蛋白-1调节的物质。如果Annexin-1被发现介导类固醇的免疫调节作用，其参与类固醇有益作用的能力可能会对关节炎和其他炎症性疾病的治疗产生重要影响。