Laser techniques and applications in mass spectrometry spectroscopy and photonics

激光技术及其在质谱光谱学和光子学中的应用

• 批准号: 106721-2006
• 负责人: Lipson, Robert
• 金额: $ 4.4万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2007
• 资助国家: 加拿大
• 起止时间: 2007-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=364996
• 关键词: Laser; techniques; applications; mass; spectrometry

The Lipson group will undertake research in mass spectrometry, molecular spectroscopy, and photonics.    In the area of mass spectrometry, Lipson and co-workers will interface a short wavelength vacuum ultraviolet (VUV, wavelengths between 100 nm and 200 nm) laser to a matrix assisted laser desorption/ionization (MALDI) mass spectrometer. The neutral molecule concentration in the MALDI is much larger than that of the primary MALDI ions created. Post-ionization of the neutrals with a VUV laser will therefore significantly enhance the sensitivity of MALDI mass spectrometry by orders of magnitude. The Lipson group will also explore the use of visible light absorbing laser dyes as MALDI matrices with a widely tunable optical parametric oscillator.    The Lipson group will use their expertise in single and multiphoton laser spectroscopy to study the high energy electronic states of small polyatomic molecules such as C2H2Br2.  The fine structure resolved in these spectra will allow excited state molecular geometries to be established for the first time.    Lipson and his students have developed new approaches to optical lithography for the fabrication of photonic band gap crystals. In this funding cycle the Lipson group will explore several new directions including: lithographic fabrication of three-dimensional crystals that are capable of operating in the visible to near infrared spectral range; synthesis and characterization of high index  polymer resists containing Si, Ge and Sn moieties so that active crystals can be made directly in one step; fabrication of quantum dot arrays, synthesis and characterization of nonlinear photonic structures that incorporate beta-barium borate (BBO), and biofilm patterning.

利普森小组将从事质谱、分子光谱和光子学方面的研究。 在质谱领域，Lipson及其同事将把短波长真空紫外（VUV，波长在100 nm和200 nm之间）激光器与基质辅助激光解吸/电离（MALDI）质谱仪连接起来。MALDI中的中性分子浓度远大于所产生的初级MALDI离子的浓度。因此，用真空紫外激光后电离中性粒子将显著提高MALDI质谱的灵敏度。Lipson小组还将探索使用可见光吸收激光染料作为MALDI矩阵，并使用可广泛调谐的光学参量振荡器。 Lipson小组将利用他们在单光子和多光子激光光谱学方面的专业知识，研究小的多原子分子（如C2 H2 Br 2）的高能电子态。这些光谱中解析的精细结构将首次建立激发态分子几何结构。 利普森和他的学生们已经开发出制造光子带隙晶体的光刻新方法。在此轮融资中，Lipson团队将探索几个新的方向，包括：能够在可见光至近红外光谱范围内工作的三维晶体的光刻制造;含有Si、Ge和Sn部分的高折射率聚合物抗蚀剂的合成和表征，以便可以一步直接制造活性晶体;量子点阵列的制造，结合β-硼酸钡（BBO）的非线性光子结构的合成和表征，以及生物膜图案化。