Regulation of ICAM-1 Expression in Human Retinal Endothelial Cells

人视网膜内皮细胞 ICAM-1 表达的调控

• 批准号: nhmrc : GNT1123684
• 负责人: Prof Justine Smith
• 金额: $ 56.6万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-icam-1-endothelial-cells/1347361
• 关键词: Regulation; ICAM; Expression; Human; Retinal

Posterior uveitis is an inflammation that occurs within the eye and may result in blindness. Present treatments are not directed specifically at the inflamed tissues, and they may be ineffective and cause toxicity. This research aims to identify molecules controlling the entry into the eye from the bloodstream of the white blood cells that cause the disease. The results should suggest new targets for safer drugs to treat patients with posterior uveitis.

后葡萄膜炎是一种发生在眼睛内的炎症，可能导致失明。目前的治疗不是专门针对发炎组织，它们可能无效并导致毒性。这项研究的目的是确定分子控制进入眼睛从血液中的白色血细胞，导致疾病。这些结果为治疗后葡萄膜炎的患者提供了更安全的药物新靶点。