Involvement of the Human Retinal Endothelial Cell in Blinding Eye Disease

人视网膜内皮细胞参与致盲眼病

• 批准号: FT130101648
• 负责人: Prof Justine Smith
• 金额: $ 66.24万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-06-30 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT130101648
• 关键词: Involvement; Human; Retinal; Endothelial; Cell

Endothelial cells line the blood vessels of the vascular networks that circulate blood through the tissues. The molecular constitution of each endothelial cell is different and specific to function, but may predispose to tissue-specific disease. Retinal endothelial cells ensure the nutrition and protection of a tissue critical to vision, but are key participants in retinal ischemic, inflammatory and infectious diseases that threaten vision. This project will investigate molecular activities of retinal endothelial cells that are relevant to retinal disease processes and explore future biological therapies directed against the human retinal endothelial cell that address efficacy and safety deficiencies of current treatments.

内皮细胞排列在血管网络的血管中，使血液循环通过组织。每个内皮细胞的分子组成是不同的和特定的功能，但可能易患组织特异性疾病。视网膜内皮细胞确保对视力至关重要的组织的营养和保护，但也是威胁视力的视网膜缺血性、炎症性和感染性疾病的关键参与者。该项目将研究与视网膜疾病过程相关的视网膜内皮细胞的分子活性，并探索未来针对人类视网膜内皮细胞的生物疗法，以解决当前治疗方法的有效性和安全性缺陷。