Novel biomarkers for neurotoxicity

神经毒性的新型生物标志物

• 批准号: 349899-2007
• 负责人: Chan, Laurie
• 金额: $ 2.91万
• 依托单位: University of Northern British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Accelerator Supplements
• 财政年份: 2007
• 资助国家: 加拿大
• 起止时间: 2007-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=365269
• 关键词: Novel; biomarkers; neurotoxicity

The over arching goal of our research program is to develop early warning markers for measuring adverseeffects of environmental contaminants on ecosystem health. Environmental exposure just above backgroundlevels rarely leads to observable immediate effects. Slow, insidious changes in biological functions, reflectingdiminished wellbeing, are more common. We have spent the last five years developing, evaluating andvalidating the use of a number of neurochemical parameters involved in the dopaminergic and muscariniccholinergic nervous systems as biomarkers for the neurotoxicity of methylmercury (MeHg) and otherenvironmental chemicals. We now have a series of neurochemical and neurofunctional tests for wildlife andhuman population studies. The objectives of the next five year program are to understand the underlyingmolecular mechanisms and to evaluate the physiological and ecological consequences of these effects.Our approach of studying the same endpoints in keystone mammalian species (including human) is novel andrelevant. We also have the capacity to use the findings from cutting-edge basic experiments for appliedwildlife and epidemiological studies. Our results may be used to establish thresholds for ecosystem healthmanagement purposes.

我们的研究计划的首要目标是开发早期预警标志物，用于测量环境污染物对生态系统健康的不利影响。仅高于背景水平的环境暴露很少会导致可观察到的直接影响。生物功能的缓慢、隐蔽的变化，反映出健康状况的下降，更为常见。在过去的五年里，我们一直在开发，评估和验证使用的一些神经化学参数参与多巴胺和毒蕈碱胆碱能神经系统作为生物标志物的甲基汞（MeHg）和其他有害化学品的神经毒性。我们现在有一系列的神经化学和神经功能测试用于野生动物和人类研究。未来五年计划的目标是了解潜在的分子机制，并评估这些影响的生理和生态后果。我们在关键哺乳动物物种（包括人类）中研究相同终点的方法是新颖和相关的。我们也有能力将尖端基础实验的结果用于应用野生动物和流行病学研究。我们的研究结果可用于建立生态系统健康管理的目的阈值。