Infrared spectroscopic studies of ionic and neutral biomolecules and their solvated complexes

离子和中性生物分子及其溶剂化复合物的红外光谱研究

基本信息

  • 批准号:
    327041-2006
  • 负责人:
  • 金额:
    $ 2.48万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Discovery Grants Program - Individual
  • 财政年份:
    2007
  • 资助国家:
    加拿大
  • 起止时间:
    2007-01-01 至 2008-12-31
  • 项目状态:
    已结题

项目摘要

The proposed research is focused on the structure elucidation of both neutral and ionic molecules and complexes, especially those which can participate in weak intramolecular bonding.  In their natural state, proteins and other biological molecules are multiply protonated. They can also be bound to metal cations and this is often required for biological activity.  The proposed research will provide insight into the salient weak intramolecular interactions which are present in biologically relevant molecules by studying the infrared spectra of these species isolated in rare-gas matrices at cryogenic temperatures where they can be stored and studied indefinately.  The degree of interaction with another portion of the molecule (intramolecular bonding) can be studied by the shifts in  position of the infrared absorption.  For example, when glycine is bound to a sodium cation, one of the isomers is expected to exhibit strong intramolecular hydrogen bonding between a carbonyl oxygen and an amino hydrogen.  The N-H stretch is seen to red-shift by some 800 wavenumbers from that of a normal N-H stretch.   The effect of sequentially solvating (with 1, 2 or more solvent molecules such as water) biologically interesting ions and neutrals will be studied in order to bridge the gap between the intrinsic properties of the gas-phase molecule and those of the molecule in its natural, solvated state.  With the proposed experiments we will be able to assess the structural changes which occur at each stage solvation. This research is expected to play an important role in determining the structure, and the effect of solvent on the structure, of life's building blocks.  This will lead to a more detailed, fundamental understanding of the role of the biomolecule and the role of solvent in biological activity.  Furthermore, this research will provide spectral signatures for biological ions and neutrals which can eventually aid in the use of infrared spectroscopy for diagnostic purposes.
该研究的重点是中性和离子分子和复合物的结构解析,特别是那些可以参与弱分子内键合的分子。在自然状态下,蛋白质和其他生物分子被多重质子化。它们也可以与金属阳离子结合,这通常是生物活性所必需的。拟议的研究将通过研究这些物种的红外光谱,深入了解存在于生物相关分子中的显著的弱分子内相互作用,这些物种在罕见的在低温下的气体基质,在那里它们可以被储存和不确定地研究。与分子的另一部分的相互作用程度例如,当甘氨酸与钠阳离子结合时,其中一种异构体在羰基氧和氨基氢之间表现出很强的分子内氢键。可以看到N-H伸缩比正常的N-H伸缩红移了大约800个波数。 顺序溶剂化(与1,2个或更多的溶剂分子,如水)生物感兴趣的离子和中性的效果将被研究,以弥合差距之间的固有性质的气相分子和分子在其自然的,溶剂化状态。与拟议的实验,我们将能够评估的结构变化发生在每个阶段的溶剂化。这项研究有望在确定生命组成部分的结构以及溶剂对结构的影响方面发挥重要作用。这将导致对生物分子的作用和溶剂在生物活性中的作用的更详细的基本理解。此外,这项研究将提供生物离子和中性粒子的光谱特征,最终有助于将红外光谱用于诊断目的。

项目成果

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Fridgen, Travis其他文献

Fridgen, Travis的其他文献

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{{ truncateString('Fridgen, Travis', 18)}}的其他基金

The Physical Chemistry-Structures, Energetics, and Reactions-of Self Assembled Metal Cationized Complexes in the Gas Phase
气相自组装金属阳离子配合物的物理化学——结构、能量和反应
  • 批准号:
    RGPIN-2019-05260
  • 财政年份:
    2022
  • 资助金额:
    $ 2.48万
  • 项目类别:
    Discovery Grants Program - Individual
The Physical Chemistry-Structures, Energetics, and Reactions-of Self Assembled Metal Cationized Complexes in the Gas Phase
气相自组装金属阳离子配合物的物理化学——结构、能量和反应
  • 批准号:
    RGPIN-2019-05260
  • 财政年份:
    2021
  • 资助金额:
    $ 2.48万
  • 项目类别:
    Discovery Grants Program - Individual
The Physical Chemistry-Structures, Energetics, and Reactions-of Self Assembled Metal Cationized Complexes in the Gas Phase
气相自组装金属阳离子配合物的物理化学——结构、能量和反应
  • 批准号:
    RGPIN-2019-05260
  • 财政年份:
    2020
  • 资助金额:
    $ 2.48万
  • 项目类别:
    Discovery Grants Program - Individual
The Physical Chemistry-Structures, Energetics, and Reactions-of Self Assembled Metal Cationized Complexes in the Gas Phase
气相自组装金属阳离子配合物的物理化学——结构、能量和反应
  • 批准号:
    RGPIN-2019-05260
  • 财政年份:
    2019
  • 资助金额:
    $ 2.48万
  • 项目类别:
    Discovery Grants Program - Individual
Experimental Studies of the Structures, Energetics, and Reactions of Gas Phase Self-Assembled Biomolecular Ionic Complexes
气相自组装生物分子离子配合物的结构、能量学和反应的实验研究
  • 批准号:
    RGPIN-2014-04429
  • 财政年份:
    2018
  • 资助金额:
    $ 2.48万
  • 项目类别:
    Discovery Grants Program - Individual
Experimental Studies of the Structures, Energetics, and Reactions of Gas Phase Self-Assembled Biomolecular Ionic Complexes
气相自组装生物分子离子配合物的结构、能量学和反应的实验研究
  • 批准号:
    RGPIN-2014-04429
  • 财政年份:
    2017
  • 资助金额:
    $ 2.48万
  • 项目类别:
    Discovery Grants Program - Individual
Experimental Studies of the Structures, Energetics, and Reactions of Gas Phase Self-Assembled Biomolecular Ionic Complexes
气相自组装生物分子离子配合物的结构、能量学和反应的实验研究
  • 批准号:
    RGPIN-2014-04429
  • 财政年份:
    2016
  • 资助金额:
    $ 2.48万
  • 项目类别:
    Discovery Grants Program - Individual
Experimental Studies of the Structures, Energetics, and Reactions of Gas Phase Self-Assembled Biomolecular Ionic Complexes
气相自组装生物分子离子配合物的结构、能量学和反应的实验研究
  • 批准号:
    RGPIN-2014-04429
  • 财政年份:
    2015
  • 资助金额:
    $ 2.48万
  • 项目类别:
    Discovery Grants Program - Individual
Experimental Studies of the Structures, Energetics, and Reactions of Gas Phase Self-Assembled Biomolecular Ionic Complexes
气相自组装生物分子离子配合物的结构、能量学和反应的实验研究
  • 批准号:
    RGPIN-2014-04429
  • 财政年份:
    2014
  • 资助金额:
    $ 2.48万
  • 项目类别:
    Discovery Grants Program - Individual
Structures, reactivities and energetics of ion-molecule complexes
离子-分子配合物的结构、反应性和能量学
  • 批准号:
    327041-2009
  • 财政年份:
    2013
  • 资助金额:
    $ 2.48万
  • 项目类别:
    Discovery Grants Program - Individual

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