Regulation from the Outside: Control of Transport and Assembly of Major Cell Wall Components in Mycobacteria

来自外部的调节：分枝杆菌中主要细胞壁成分的运输和组装的控制

• 批准号: nhmrc : 1064466
• 负责人: Dr Paul Crellin
• 金额: $ 43.48万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-outside-control-components-mycobacteria/455121
• 关键词: Regulation; Outside; Control; Transport; Assembly

Tuberculosis (TB) kills nearly two million people each year while the causative bacterial species, Mycobacterium tuberculosis, infects one-third of the entire human population. An alarmingly high rate of TB exists in Australia's indigenous population. This proposal aims to identify and characterise essential processes that regulate synthesis of the outer coat of the bacterium, which are potential targets for new drugs for the treatment of this devastating disease.

结核病(TB)每年导致近200万人死亡，而引起结核病的细菌物种结核分枝杆菌感染了三分之一的人类人口。澳大利亚土著人口中的结核病发病率高得令人震惊。这项提议旨在确定和表征调节细菌外层合成的基本过程，这些过程是治疗这种毁灭性疾病的新药的潜在靶点。