Investigating the Mechanisms of Regulation of Mycobacterial Cell Wall Biosynthesis

研究分枝杆菌细胞壁生物合成的调节机制

• 批准号: nhmrc : 1007676
• 负责人: Dr Paul Crellin
• 金额: $ 39.83万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigating-mechanisms-regulation-wall-biosynthesis/109237
• 关键词: Investigating; Mechanisms; Regulation; Mycobacterial; Cell

Tuberculosis (TB) kills around two million people each year while the causative bacterial species, Mycobacterium tuberculosis, infects one-third of the entire human population. An alarmingly high rate of TB exists in Australia's indigenous population. This proposal aims to identify and characterise essential processes involved in synthesis of the outer coat of the bacterium which are potential targets for new drugs for the treatment of this devastating disease.

结核病（TB）每年造成约200万人死亡，而致病细菌结核分枝杆菌（Mycobacterium tuberculosis）感染了三分之一的人口。澳大利亚土著居民的结核病发病率高得惊人。该提案旨在确定和鉴定参与细菌外壳合成的基本过程，这些过程是治疗这种毁灭性疾病的新药的潜在靶点。