Regulation of pilus biogenesis in Neisseria

奈瑟菌菌毛生物发生的调节

• 批准号: nhmrc : 546004
• 负责人: Prof John Davies
• 金额: $ 18.7万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-pilus-biogenesis-neisseria/96889
• 关键词: Regulation; pilus; biogenesis; Neisseria

A group of bacteria called Neisseria cause human-specific infections. To initiate infection, the bacteria must produce a hair-like surface structure, the pilus. The pilus consists mainly of a protein called pilin, and we now understand how pilin production is controlled. However 20 other genes are also involved in pilus production. This project aims to understand how these other genes are controlled and coordinated to assemble this structure that is central to the ability to cause disease.

一组称为奈瑟氏菌的细菌会引起人类特有的感染。为了引发感染，细菌必须产生一种毛发状的表面结构，即菌毛。菌毛主要由一种叫做菌毛蛋白的蛋白质组成，我们现在了解了菌毛蛋白的产生是如何控制的。然而，其他20个基因也参与菌毛的产生。该项目旨在了解这些其他基因是如何控制和协调组装这种结构的，这种结构是导致疾病的能力的核心。