Group 10 metal macrocycles and chelates: supramolecular chemistry; biopolymer modification and anti-cancer properties

第 10 族金属大环化合物和螯合物：超分子化学；

• 批准号: 196035-2006
• 负责人: Haines, Robert
• 金额: $ 1.46万
• 依托单位: University of Prince Edward Island
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2007
• 资助国家: 加拿大
• 起止时间: 2007-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=366439
• 关键词: Group; 10; metal; macrocycles; chelates

We are interested in the development of new materials based on macrocycles - which are ring-shaped molecules that can bind to a wide range of metals forming very stable compounds.  One goal is to attach macrocycles to chitosan - a biopolymer made by modifying chitin (which itself is the major biopolymer present in lobster and crab shells).  The new materials may have important properties, and we plan to study their ability to (a) bind metal ions (for purification of polluted waters); and (b) bind phosphate ion (which would be useful in removing phosphate toxins from dialysis patients).      A second goal of our work is to continue to explore the interaction of "pendant-arm macrocycles" (which, as the name implies, are macrocycles that have other molecules appended) with cyclodextrins (which are chains of 6 or 7 sugar molecules connected in a ring).  These interactions are termed "supramolecular", since they do not involve bonding of the two reaction species, but involve non-bonding, intermolecular forces of attraction.  Supramolecular chemistry is a rapidly growing and important field, where many studies of non-bonding interaction between organic or inorganic compounds have been explored. There is, however, a paucity of research on transition metal macrocycles, and we plan to explore this area.      The third goal of our research is to make new materials containing palladium metal, to study their reactivity and determine if they are effective in killing human cancer cells. This work is carried out in vitro, where commercially available human cancer cells (ovarian, breast and colon, for example) are treated with the new compounds, using cisplatin as a control, to determine their efficacy as potential anti-cancer agents. This research not only adds to our understanding of mechanisms of reactions of transition metal macrocycles, but may have important application to human health.  The research program also provides research training to undergraduate and graduate students, who will learn research methods valuable to their future careers.

我们对开发基于大环的新材料很感兴趣，大环是一种环状分子，可以与各种金属结合形成非常稳定的化合物。其中一个目标是将大环连接到壳聚糖上——壳聚糖是一种通过修饰几丁质制成的生物聚合物（它本身就是龙虾和螃蟹壳中的主要生物聚合物）。新材料可能具有重要的性能，我们计划研究它们(a)结合金属离子（用于净化污染的水）的能力；(b)结合磷酸盐离子（这将有助于清除透析患者体内的磷酸盐毒素）。我们工作的第二个目标是继续探索“垂臂大环”（顾名思义，是附加了其他分子的大环）与环糊精（由6或7个糖分子组成的链连接成一个环）的相互作用。这些相互作用被称为“超分子”，因为它们不涉及两个反应物种的成键，而是涉及非成键的分子间引力。超分子化学是一个快速发展的重要领域，对有机或无机化合物之间的非键相互作用进行了许多研究。然而，对过渡金属大环的研究很少，我们计划在这一领域进行探索。我们研究的第三个目标是制造含有钯金属的新材料，研究它们的反应性，并确定它们是否能有效杀死人类癌细胞。这项工作是在体外进行的，用新化合物治疗市售的人类癌细胞（例如卵巢癌、乳腺癌和结肠癌），使用顺铂作为对照，以确定它们作为潜在抗癌剂的功效。该研究不仅增加了我们对过渡金属大环反应机理的认识，而且对人类健康具有重要的应用价值。该研究项目还为本科生和研究生提供研究培训，他们将学习对未来职业有价值的研究方法。