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Environment Exposure & Neurotoxicology Core

Environment Exposure & Neurotoxicology Core
环境暴露
批准号:
10216925
负责人:
Constantinos Sioutas
金额:
$25.47万
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-07-01 至 2023-06-30

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中文摘要
翻译
环境暴露和神经毒理学核心(核心C) 导演,C Sioutas,联合导演:JC Chen和H Forman 摘要 环境暴露和神经毒理学核心C,由C。Sioutas,包括三个支持 通过提供特定驻地的接触, 人群中的估计值,动物模型中吸入暴露实验的标准化,以及 交通相关空气污染(traffic related air pollution,TRAP)。SubCore C1,环境数据 Support(coDir:JC Chen)为项目1和项目2提供了个人层面的、特定于地点的长期 长期陷阱暴露,使用最先进的时空建模方法,在两个 基于人类群体的队列。Subcore C2,Collection of TRAP-nPM(Dir:C.Sioutas) 实验项目3和4具有良好表征的TRAP吸入暴露气氛。阱 在受交通排放影响的城市附近采样。亚核心C3,脑细胞对TRAP-PM的反应 (coDir:H.(i)使用THP-1细胞测试单个批次的收集的nPM的细胞因子表达;和 (ii)对于项目3和4,脑蛋白质对体内nPM暴露的改变的蛋白质印迹测定。
英文摘要
Environmental Exposures and Neurotoxicology Core (Core C) Director, C Sioutas, Co-Directors: JC Chen and H Forman Abstract The Environmental Exposures and Neurotoxicology Core C, directed by C. Sioutas, includes three supporting subcores to serve the proposed scientific projects, through the provision of the residence-specific exposure estimates in populations, standardization of the inhalation exposure experiments in animal models, and analyses of the neurotoxic responses to traffic-related air pollution (TRAP). SubCore C1, Environmental Data Support (coDir: JC Chen) provides Projects 1 and 2 with individual-level, location-specific estimates of long- term TRAP exposure, using state-of-the-art spatio-temporal modeling approaches harmonized across two human population-based cohorts. Subcore C2, Collection of TRAP-nPM (Dir: C.Sioutas) supplies experimental Projects 3 and 4 with well-characterized TRAP inhalation exposure atmospheres. TRAP are sampled near urban sites impacted by traffic emissions. SubCore C3, Brain Cell Responses to TRAP-PM (coDir: H. Forman) (i) tests individual batches of collected nPM using THP-1 cells for cytokine expression; and (ii) Western blot assay of brain protein changes to in vivo nPM exposure for Projects 3 & 4.
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Environment Exposure & Neurotoxicology Core
  • 批准号:
    10456751
  • 项目类别:
  • 资助金额:
    $23.23万
  • 财政年份:
    2018
  • 负责人:
    Constantinos Sioutas
  • 依托单位:
Environment Exposure & Neurotoxicology Core
  • 批准号:
    9491505
  • 项目类别:
  • 资助金额:
    $35.31万
  • 财政年份:
    --
  • 负责人:
    Constantinos Sioutas
  • 依托单位:
海外基金