Role of adenosine A2A receptors in cytoprotection

腺苷 A2A 受体在细胞保护中的作用

• 批准号: 250234-2007
• 负责人: Rousseau, Guy
• 金额: $ 1.78万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2007
• 资助国家: 加拿大
• 起止时间: 2007-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=366464
• 关键词: Role; adenosine; A2A; receptors; cytoprotection

We have demonstrated that the stimulation of A2A adenosine receptors induced a reduction in cell death. However, the molecular mechanisms for this beneficial effect are poorly understood. We hypothesize that this is partly due to the conditions used to study this receptor. Notably, the concentration of adenosine, which is the natural substance reacting with this receptor, increases during specific conditions such as oxygen reduction. Few studies have taken this important point into consideration.In the first part of this proposal, we have decided to study the intracellular changes observed following the activation of this receptor in different conditions varying from normal to reduced oxygen availability.In the second step of this proposal, we will perform study to determine which enzyme(s) modulated by this receptor is/are important to protect from specific death cell called apoptosis.At the end of this program, we should have a better idea of the molecular mechanisms involved in the protective effect of this receptor.

我们已经证明，A2 A腺苷受体的刺激诱导细胞死亡减少。然而，这种有益效果的分子机制知之甚少。我们推测，这部分是由于用于研究这种受体的条件。值得注意的是，腺苷的浓度，这是与这种受体反应的天然物质，增加在特定条件下，如氧气减少。很少有研究考虑到这一点。在本提案的第一部分，我们决定研究在从正常氧可用性到减少氧可用性的不同条件下激活该受体后观察到的细胞内变化。在本提案的第二步，我们将进行研究，以确定这种受体调节的酶是/对于保护特定的死亡细胞（称为凋亡）是很重要的。在本节目结束时，我们应该对这种受体保护作用的分子机制有更好的了解。