Role of adenosine A2A receptors in cytoprotection

腺苷 A2A 受体在细胞保护中的作用

• 批准号: 250234-2007
• 负责人: Rousseau, Guy
• 金额: $ 1.78万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=426288
• 关键词: Role; adenosine; A2A; receptors; cytoprotection

We have demonstrated that the stimulation of A2A adenosine receptors induced a reduction in cell death. However, the molecular mechanisms for this beneficial effect are poorly understood. We hypothesize that this is partly due to the conditions used to study this receptor. Notably, the concentration of adenosine, which is the natural substance reacting with this receptor, increases during specific conditions such as oxygen reduction. Few studies have taken this important point into consideration.

我们已经证明，A2A腺苷受体的刺激诱导细胞死亡减少。然而，这种有益效果的分子机制知之甚少。我们推测，这部分是由于用于研究这种受体的条件。值得注意的是，腺苷的浓度，这是与这种受体反应的天然物质，增加在特定条件下，如氧气减少。很少有研究考虑到这一重要问题。