Regulation of ribosomal RNA gene chromatin during malignant transformation.

恶性转化过程中核糖体RNA基因染色质的调节。

• 批准号: nhmrc : 1100654
• 负责人: Dr Elaine Sanij
• 金额: $ 60.65万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-ribosomal-rna-malignant-transformation/662522
• 关键词: Regulation; ribosomal; RNA; gene; chromatin

The overarching goal of this proposal is to determine the molecular basis for tumour cell dependence on activated ribosomal RNA gene repeats (rDNA). Our working model posits that rDNA repeats become activated through changes in rDNA chromatin structure that include increased binding of the RNA Polymerase I transcription factor UBF.

该建议的总体目标是确定肿瘤细胞依赖于活化核糖体RNA基因重复序列（rDNA）的分子基础。我们的工作模型假设rDNA重复序列通过rDNA染色质结构的变化而被激活，包括RNA聚合酶I转录因子UBF的结合增加。