Genomic analysis of DNA binding and gene regulation by the chromatin remodelling factor UBF

DNA 结合的基因组分析和染色质重塑因子 UBF 的基因调控

• 批准号: nhmrc : 1043143
• 负责人: Dr Elaine Sanij
• 金额: $ 41.63万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/genomic-analysis-dna-factor-ubf/111548
• 关键词: Genomic; analysis; DNA; binding; gene

Synthesis of ribosomes, the cellular protein synthetic machinery, is the major anabolic event of a growing cell and is frequently dysregulated during disease such as cancer. This grant will examine a protein termed UBF that we think plays an important role in orchestrating the cellular response to dysregulated ribosome biogenesis. By understanding how UBF functions we hope to uncover novel therapeutic approaches to treat diseases associated with ribosome stress .

核糖体的合成，细胞蛋白质合成机器，是生长细胞的主要合成代谢事件，并且在疾病如癌症期间经常失调。这项资助将研究一种名为UBF的蛋白质，我们认为这种蛋白质在协调细胞对核糖体生物合成失调的反应中起着重要作用。通过了解UBF的功能，我们希望发现新的治疗方法来治疗与核糖体应激相关的疾病。