Regulator of G-protein Signalling-5: a key modulator of vascular maturation and the

G 蛋白信号传导调节因子 5：血管成熟和血管成熟的关键调节因子

• 批准号: nhmrc : 458627
• 负责人: Karin Eidne
• 金额: $ 36.57万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulator-g-protein-vascular-maturation/97435
• 关键词: Regulator; protein; Signalling; key; modulator

Tumours progressively grow in part because they escape destruction by the immune system. New blood vessels grow inside tumours by a process called angiogenesis, which in turn stops disease-fighting cells in their tracks. However, we have now discovered that it is possible to reverse angiogenesis by normalising the blood vessels. This effectively means the barriers are broken down and the tumour can be opened to the immune system or cancer fighting drugs. Furthermore, we have identified a protein which appears to be very important for normalisation, a process which is currently not well understood. This proposal continues our pioneering work on vessel normalisation and will use models of highest clinical relevance to study the dynamics of vessel remodelling in tumours. Our approach is different to current angiogenesis research which simply tries to block or destroy the blood vessels that feed tumours. We expect our findings to lead to highly specific and effective anti-tumour therapies. Moreover, vessel growth in tumours has striking parallels to other vascular processes in the body, which have important implications for major and common human diseases such as high blood pressure and atherosclerosis. We now have the tools to study these processes and their abnormalities in our newly established disease model. By gaining insight into these disorders we will be able to develop novel approaches to stop disease progression.

肿瘤逐渐生长的部分原因是它们逃避了免疫系统的破坏。新的血管通过一个叫做血管生成的过程在肿瘤内生长，这反过来又会阻止疾病抵抗细胞的运动。然而，我们现在已经发现，通过使血管正常化来逆转血管生成是可能的。这有效地意味着屏障被打破，肿瘤可以向免疫系统或抗癌药物开放。此外，我们已经确定了一种蛋白质，似乎是非常重要的正常化，这是一个过程，目前还没有很好地理解。该提案继续了我们在血管正常化方面的开创性工作，并将使用最高临床相关性的模型来研究肿瘤中血管重塑的动力学。我们的方法与目前的血管生成研究不同，后者只是试图阻止或破坏滋养肿瘤的血管。我们希望我们的研究结果能够导致高度特异性和有效的抗肿瘤疗法。此外，肿瘤中的血管生长与体内的其他血管过程有着惊人的相似之处，这对高血压和动脉粥样硬化等主要和常见的人类疾病具有重要意义。我们现在有工具在我们新建立的疾病模型中研究这些过程及其异常。通过深入了解这些疾病，我们将能够开发新的方法来阻止疾病进展。