The relationship between vascular remodelling and mast cells in chronic asthma

慢性哮喘血管重塑与肥大细胞的关系

• 批准号: nhmrc : 566904
• 负责人: A/Pr Kenneth Snibson
• 金额: $ 23.55万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/relationship-vascular-remodelling-chronic-asthma/77400
• 关键词: relationship; between; vascular; remodelling; mast

It is known that the airwalls of asthmatics have increased numbers of small blood vessels which can contribute to poor lung function in asthma. The proposed research uses a novel sheep model for chronic asthma to investigate the progressive changes to the blood vessels in the airway walls of asthmatic lungs. The information gained from our sheep model will assist the understanding of blood vessel growth and thus ulitmately help in devising new strategies to treat the effects of asthma.

众所周知，哮喘患者气壁的小血管数量增加，这可能导致哮喘患者的肺功能不良。拟议的研究使用一种新型的慢性哮喘绵羊模型来研究哮喘肺部气道壁血管的渐进性变化。从我们的绵羊模型中获得的信息将有助于了解血管生长，从而最终有助于制定治疗哮喘影响的新策略。