Targeting small airways to overcome resistance to therapy in asthma

针对小气道克服哮喘治疗的抵抗力

• 批准号: nhmrc : 1041575
• 负责人: A/Pr Kenneth Snibson
• 金额: $ 35.41万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-small-airways-therapy-asthma/111379
• 关键词: Targeting; small; airways; overcome; resistance

There is a pressing need to overcome resistance to current therapies for severe asthma. Targetting inflammation-induced changes in small airway contraction offers an alternative strategy. We have identified a novel bronchodilator that relaxes maximally contracted mouse small airways when current treatment is ineffective. We will demonstrate its efficacy in animal models mimicking key features of human asthma, and define new ways to improve outcomes in poorly-controlled asthma.

迫切需要克服对目前治疗严重哮喘的抗药性。以炎症引起的小气道收缩变化为靶点提供了另一种策略。我们已经确定了一种新的支气管扩张剂，当目前的治疗无效时，它可以松弛最大限度收缩的小鼠小气道。我们将在模拟人类哮喘关键特征的动物模型中展示其有效性，并定义改善控制不佳哮喘结果的新方法。