RENAL VASCULAR HYPERTROPHY AND REMODELLING IN SHR: SYMPATHETIC NERVOUS SYSTEM AND IMPLICATIONS FOR HYPERTENSION

SHR 中的肾血管肥大和重构：交感神经系统及其对高血压的影响

• 批准号: nhmrc : 124404
• 负责人: Dr Michelle Kett
• 金额: $ 12.77万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2000
• 资助国家: 澳大利亚
• 起止时间: 2000-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/renal-vascular-hypertrophy-implications-hypertension/99760
• 关键词: RENAL; VASCULAR; HYPERTROPHY; REMODELLING; SHR

High blood pressure (hypertension) remains a major health problem for Australians. One in six Australians suffer from hypertension, with consequent increased risk of stroke and heart attack. Anti-hypertensive treatments are available, but must usually be taken for the rest of the patient's life and the cost to the taxpayer of anti-hypertensive drugs is greater than for any other health problem. Prevention of high blood pressure depends on identifying the initial cause - but we still do not know the cause in over 90% of hypertensive people. This project will study whether overactivity of the nerves to the blood vessels of the kidney might be the cause. There is evidence for this in humans, and in a strain of rats which develops high blood pressure (the spontaneously hypertensive rat). Our experiments will study these rats to see whether nerves affect the structure and function of the blood vessels of the kidney in ways that lead to increased blood pressure.

高血压仍然是澳大利亚人的主要健康问题。六分之一的澳大利亚人患有高血压，从而增加中风和心脏病发作的风险。可以进行抗高血压治疗，但通常必须在患者的余生中服用，并且纳税人在抗高血压药物方面的费用比任何其他健康问题都要高。预防高血压取决于找出最初的病因——但我们仍然不知道超过 90% 的高血压患者的病因。该项目将研究肾脏血管神经过度活跃是否可能是原因。在人类和患有高血压的大鼠品系（自发性高血压大鼠）中，有证据表明这一点。我们的实验将研究这些老鼠，看看神经是否会影响肾脏血管的结构和功能，从而导致血压升高。