To repair an osteo-chondral defect in an experimental rabbit model using a structured 3D nano-composite scaffold loaded with Mesenchymal Stem Cells (MSC)

使用装载间充质干细胞 (MSC) 的结构化 3D 纳米复合材料支架修复实验兔模型中的骨软骨缺损

• 批准号: nhmrc : 1017633
• 负责人: Dr Ken Ye
• 金额: $ 6.16万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Postgraduate Scholarships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/repair-an-osteo-cells-msc/109884
• 关键词: repair; osteo; chondral; defect; experimental

The treatment of cartilage damage is a major problem in orthopaedic practice. The use of a 3D scaffold may overcome many challenges associated with cartilage and bone repair and regeneration. The aim of this research is to culture bone and cartilage cells into a prefabricated scaffold which may then be tested in an animal model. The results of this research may offer a new method of treating post-traumatic and osteoarthritic defects.

软骨损伤的治疗是骨科实践中的一个主要问题。3D支架的使用可以克服与软骨和骨修复和再生相关的许多挑战。这项研究的目的是将骨和软骨细胞培养成预制支架，然后可以在动物模型中进行测试。本研究结果可能为治疗创伤后和骨关节炎性缺损提供一种新方法。