How replication stress activates the mitotic telomere DNA damage response to kill cancer cells

复制压力如何激活有丝分裂端粒 DNA 损伤反应来杀死癌细胞

• 批准号: nhmrc : 1106241
• 负责人: Dr Anthony Cesare
• 金额: $ 33.52万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/replication-stress-activates-cancer-cells/662895
• 关键词: How; replication; stress; activates; mitotic

We discovered a novel mechanism linking stress during DNA replication to difficulties with the cell division process, and identified how this turns on DNA damage response signals from the chromosome ends (i.e. “telomeres”). We have further identified that we can exploit this mechanism to kill cancer cells. In this project we will explore this newly discovered mechanism and identify how it can be targeted for therapeutic purposes.

我们发现了一种新的机制，将DNA复制过程中的压力与细胞分裂过程中的困难联系起来，并确定了这是如何从染色体末端(即“端粒”)启动DNA损伤反应信号的。我们进一步确认，我们可以利用这一机制来杀死癌细胞。在这个项目中，我们将探索这一新发现的机制，并确定如何将其用于治疗目的。