The role of nuclear architecture in the DNA damage response

核结构在 DNA 损伤反应中的作用

• 批准号: nhmrc : GNT1104461
• 负责人: Dr Anthony Cesare
• 金额: $ 56.2万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-nuclear-architecture-damage-response/1346361
• 关键词: role; nuclear; architecture; DNA; damage

The goal of the proposed research is to understand how dynamic changes to the chromatin genome packaging network, interact with the DNA damage response and gene expression machinery, to repair damaged DNA and the impact this has on cancer biology. To do so we are combining cutting edge molecular biology techniques with innovative novel microscopy methods developed by our research team, that far exceed the spatiotemporal resolution currently used to study chromatin biology.

这项研究的目标是了解染色质基因组包装网络的动态变化如何与DNA损伤反应和基因表达机制相互作用，修复受损的DNA及其对癌症生物学的影响。为此，我们将尖端的分子生物学技术与我们研究团队开发的创新显微镜方法相结合，远远超过目前用于研究染色质生物学的时空分辨率。