Research Fellowship

研究奖学金

• 批准号: nhmrc : 1022870
• 负责人: A/Pr Joan Heath
• 金额: $ 40.78万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/research-fellowship/110225
• 关键词: Research; Fellowship

Cancer is linked to mutations in a large variety of genes but how these changes impact on cell behaviour is often unknown. We are using functional genomics in zebrafish to identify genes that are essential for rapid rates of proliferation by intestinal epithelial cells. Seven genes have been cloned so far and our next task is to analyse, using mouse models and human cancer transcriptome analysis, whether any are indispensable for cancer growth and thereby present suitable targets for therapy.

癌症与多种基因的突变有关，但这些变化对细胞行为的影响通常是未知的。我们正在使用斑马鱼的功能基因组学来识别对肠道上皮细胞快速增殖至关重要的基因。到目前为止，我们已经克隆了7个基因，我们的下一个任务是利用小鼠模型和人类癌症转录组分析，分析是否有任何基因对癌症生长是不可或缺的，从而提出合适的治疗靶点。