The role of Rnpc3 in U12-type mRNA splicing, gene expression and cancer

Rnpc3 在 U12 型 mRNA 剪接、基因表达和癌症中的作用

• 批准号: nhmrc : 1024878
• 负责人: A/Pr Joan Heath
• 金额: $ 39.59万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-rnpc3-u12-expression-cancer/110382
• 关键词: role; Rnpc3; U12; type; mRNA

The zebrafish is a small tropical fish that is an alternative model to mice for genetic studies. We have used zebrafish to discover genes that are essential for the rapid development of the intestine in the belief that these genes are also essential for tumour growth. We will test whether the loss of RNPC3 (the human version of one of our genes), which is required for the production of a small number of proteins that can suppress the development of cancer, plays a hitherto unappreciated causal role in the development of colon tumours.

斑马鱼是一种小型热带鱼，是遗传研究中小鼠的替代模型。我们利用斑马鱼发现了肠道快速发育所必需的基因，相信这些基因也是肿瘤生长所必需的。我们将测试RNPC 3（我们基因之一的人类版本）的丢失是否在结肠肿瘤的发展中起着迄今为止未被认识到的因果作用，RNPC 3是产生少量蛋白质所必需的，这些蛋白质可以抑制癌症的发展。