Respiratory viral infections as triggers of acute severe asthma exacerbations in atopics: mechanistic studies in an experimental model

呼吸道病毒感染是特应性哮喘急性加重的诱因：实验模型中的机制研究

• 批准号: nhmrc : 1008741
• 负责人: Dr Deborah Strickland
• 金额: $ 43.98万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/respiratory-viral-infections-experimental-model/109338
• 关键词: Respiratory; viral; infections; triggers; acute

An important unresolved issue in asthma research is why almost all the children who present in hospital emergency with very severe asthma attacks are both allergic and virally infected. This project will seek to define how immune responses to viruses and aeroallergens interact to create very severe inflammation in the airways thus precipitating the severest type of asthma attacks. Understanding the underlying mechanisms will hopefully provide new clues towards better treatments.

哮喘研究中一个重要的未解决的问题是，为什么几乎所有在医院急诊室出现非常严重的哮喘发作的儿童都是过敏和病毒感染。该项目将试图确定对病毒和空气过敏原的免疫反应如何相互作用，从而在气道中产生非常严重的炎症，从而引发最严重的哮喘发作。了解潜在的机制将有望为更好的治疗提供新的线索。