Oklahoma Center for Respiratory and Infectious Diseases

整体 项目摘要 这一CoBRE第三阶段申请寻求支持，以发展可持续的研究设施，以进一步提高 国家竞争力的多机构生物医学研究中心-俄克拉荷马州中心呼吸和 传染病（OCRID）。2013年通过第一阶段CoBRE赠款成立，并于2018年维持 通过第二阶段的CoBRE拨款，OCRID已成为扩大呼吸道传染病 俄克拉荷马州的疾病研究。总部设在俄克拉荷马州州立大学（OSU），OCRID调查人员来自 俄克拉荷马州的主要研究机构，包括俄勒冈州立大学和俄克拉荷马大学的9所学院 俄克拉荷马州，以及一个独立的研究机构，俄克拉荷马州医学研究基金会。为 俄勒冈州立大学收到的第一笔CoBRE赠款，第一阶段和第二阶段的奖励产生了变革性的影响 关于俄克拉荷马州呼吸道传染病研究的前景。OCRID从事关键研究 关于呼吸道传染病，重点是流感病毒、呼吸道合胞病毒、呼吸道 细菌和真菌感染，现在又是新冠肺炎OCRID的跨学科项目包括治疗学， 疫苗、诊断、疾病发病机理、营养和生物工程。在联合国成功的基础上， 第一阶段和第二阶段的奖励，这第三阶段的总体目标是进一步维持一个CoBRE应用程序 卓越的研究中心在呼吸道传染病领域通过持续发展 在一个合作的环境中的研究设施。目标1将继续发展研究核心设施， 先进技术，并将其转化为可持续的机构核心设施。我们将继续 为CoBRE项目和其他调查人员提供核心专业知识和服务， 核心，开发最先进的新技术，以满足中心研究人员的需求，并扩大 核心服务。完成这些核心设施向自我维持的体制设施过渡的战略计划 研究设施包括成本回收、机构支持、确保设备、资源和技术 以及合作赠款、行业合作伙伴和慈善事业。目标2将进一步加强研究 通过试点项目计划和机构间合作来维持有影响力的研究环境。 我们将继续扩大呼吸系统疾病专题领域多学科研究人员的临界质量， 通过培养初级研究人员和将已建立的研究人员重新定向到呼吸系统疾病 传染病研究通过试点项目计划，并聘请新的终身教职员工， 研究是该中心的重点。我们还将继续提供研究和职业发展 活动和促进机构间的合作，在俄克拉荷马州通过研究研讨会系列，工作， 进展和期刊俱乐部会议，年度呼吸道和传染病研究研讨会和 开发多研究者补助金申请。

Overall Project Summary This CoBRE Phase III application seeks support to develop sustainable research facilities to further enhance a nationally competitive multi-institutional biomedical research center—the Oklahoma Center for Respiratory and Infectious Diseases (OCRID). Established in 2013 through the Phase I CoBRE grant and sustained in 2018 through the Phase II CoBRE grant, OCRID has become a focal point for expanding respiratory infectious disease research in Oklahoma. Based at Oklahoma State University (OSU), OCRID investigators come from major research institutions across the state of Oklahoma, including 9 colleges at OSU and the University of Oklahoma, as well as an independent research institute, the Oklahoma Medical Research Foundation. As the first CoBRE grants ever received by OSU, the Phase I and Phase II awards have had a transformative effect on the landscape of respiratory infectious disease research in Oklahoma. OCRID engages in critical research on respiratory infectious diseases with a focus on influenza virus, respiratory syncytial virus, respiratory bacterial and fungal infections, and now COVID-19. The interdisciplinary projects in OCRID cover therapeutics, vaccines, diagnostics, disease pathogenesis, nutrition, and bioengineering. Building on the success of the Phase I and Phase II awards, the overall objective of this Phase III CoBRE application is to further sustain a research center of excellence in the field of respiratory infectious diseases through the continued development of research facilities in a collaborative environment. Aim 1 will continue to develop research core facilities with cutting-edge technologies and transform them into sustainable institutional core facilities. We will continue to provide core expertise and services to CoBRE projects and other investigators, modernize the established cores, develop state-of-the-art new technologies to meet the needs of the center investigators, and broaden core services. A strategic plan to complete the transition of these core facilities into self-sustained institutional research facilities includes cost recovery, institutional support, securing equipment, resource and technology and collaborative grants, industry partners and philanthropy. Aim 2 will further enhance the research environment to sustain impactful research via a pilot projects program and interinstitutional collaborations. We will continue to expand the critical mass of multidisciplinary investigators in the thematic area of respiratory infectious diseases by nurturing junior investigators and redirecting established investigators into respiratory infectious disease research via a pilot projects program and hiring new tenure-track faculty members whose research is within the focus of the Center. We will also continue to provide research and career development activities and promote interinstitutional collaborations in Oklahoma via a research seminar series, work-in- progress and journal club meetings, an annual respiratory and infectious disease research symposium and the development of multi-investigator grant applications.