Methylation sensitive genes and the transition to allergic disease: a twin study

甲基化敏感基因与过敏性疾病的转变：一项双胞胎研究

• 批准号: nhmrc : 1063394
• 负责人: Dr Deborah Strickland
• 金额: $ 32.93万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/methylation-sensitive-genes-twin-study/455054
• 关键词: Methylation; sensitive; genes; transition; allergic

Australia has amongst the highest reported prevalence allergic conditions (including asthma) in the world. Despite this, little is known about how these conditions arise. Mounting evidence implicates environmentally induced disruption of the genetic blueprint via a process known as epigenetics. We are combining the strengths of a unique collection of identical twins where one of a pair is sensitive to house dust mite, with cutting edge genomics, to characterise the pathways leading to allergy in children.

澳大利亚是世界上报告的过敏性疾病（包括哮喘）患病率最高的国家之一。尽管如此，人们对这些条件是如何产生的知之甚少。越来越多的证据表明，环境通过一个被称为表观遗传学的过程引起了遗传蓝图的破坏。我们正在结合一个独特的同卵双胞胎集合的优势，其中一对屋尘螨敏感，与尖端的基因组学，以消除导致儿童过敏的途径。