Restoration of diabetes associated cognitive deficits through the modulation of cerebrovascular integrity

通过调节脑血管完整性恢复糖尿病相关的认知缺陷

• 批准号: nhmrc : 1122734
• 负责人: Dr Ryusuke Takechi
• 金额: $ 28.74万
• 依托单位: Curtin University
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/restoration-diabetes-associated-cerebrovascular-integrity/947008
• 关键词: Restoration; diabetes; associated; cognitive; deficits

Diabetes is known to increase the risk of dementia. Although the mechanisms are currently unknown, a recently emerging body of evidence suggest that damaged blood vessels of the brain may be central to onset and progress of cognitive dysfunction. Consistently, the dysfunction of brain blood vessels is often observed in the brain of diabetes subjects. Therefore, this project will investigate whether the amelioration of disrupted brain blood vessels restores the cognitive function in diabetes.

糖尿病会增加患痴呆症的风险。虽然机制目前尚不清楚，但最近出现的证据表明，大脑血管受损可能是认知功能障碍发作和进展的核心。因此，在糖尿病患者的脑中经常观察到脑血管功能障碍。因此，本项目将研究改善受损的脑血管是否能恢复糖尿病患者的认知功能。