RNA-mediated regulation of the histone methyltransferase PRC2: a new link to disease-associated and causing mutations.

RNA 介导的组蛋白甲基转移酶 PRC2 的调节：与疾病相关和引起突变的新联系。

• 批准号: nhmrc : GNT1162921
• 金额: $ 67.17万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/rna-mediated-regulation-causing-mutations/1379263
• 关键词: RNA; mediated; regulation; histone; methyltransferase

Genes in all human cells are switched 'on' and 'off' in a process that is affected by specific proteins. The immediate product of genes, a molecule termed RNA, can change the way proteins affect gene expression. In this study, we aim to understand how RNA regulate the function of specific proteins, that normally maintain thousands of genes in an 'off' state. We will determine how these proteins are altered during disease, when they can no longer be affected by RNA.

所有人类细胞中的基因都在一个受特定蛋白质影响的过程中被“打开”和“关闭”。基因的直接产物，一种称为RNA的分子，可以改变蛋白质影响基因表达的方式。在这项研究中，我们的目标是了解RNA如何调节特定蛋白质的功能，这些蛋白质通常使数千个基因处于“关闭”状态。我们将确定这些蛋白质在疾病期间如何改变，当它们不再受RNA影响时。