Role of androgens in polycystic ovary syndrome

雄激素在多囊卵巢综合征中的作用

• 批准号: nhmrc : 1022648
• 负责人: Dr Charles Allan
• 金额: $ 34.56万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-androgens-polycystic-ovary-syndrome/110201
• 关键词: Role; androgens; polycystic; ovary; syndrome

Polycystic ovary syndrome (PCOS) affects 5-10% of women worldwide, yet its origins remain unknown. Androgens are implicated in the development of PCOS, but the decisive, invasive studies needed to confirm and elucidate their roles are not feasible in women. Hence, using our innovative mouse models of androgen resistant female mice, this study will determine the role of androgens in PCOS aiming to better understand, and identify new treatments for this common female reproductive disorder.

多囊卵巢综合征（PCOS）影响着全世界5-10%的女性，但其起源仍不清楚。雄激素与PCOS的发展有关，但需要进行决定性的侵入性研究来证实和阐明它们的作用，但在女性中不可行。因此，使用我们的雄激素抵抗雌性小鼠的创新小鼠模型，本研究将确定雄激素在PCOS中的作用，旨在更好地了解和确定这种常见女性生殖疾病的新治疗方法。