Androgen receptor mechanims in female reproductive physiology

女性生殖生理学中的雄激素受体机制

• 批准号: nhmrc : 632678
• 负责人: Dr Charles Allan
• 金额: $ 35.99万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/androgen-receptor-mechanims-reproductive-physiology/77551
• 关键词: Androgen; receptor; mechanims; female; reproductive

Infertility occurs in one in six Australian couples with 50% attributable to females, thus, enhancing our understanding of ovarian and uterine function is of great importance. This project tests the proposal that androgens (steroid hormones) play a major role in regulating female reproductive physiology through their interaction with the androgen receptor. We have developed novel mouse models which we will use to determine the roles of androgens in regulating female reproductive function.

在澳大利亚，每六对夫妇中就有一对发生不孕症，其中50%归因于女性，因此，提高我们对卵巢和子宫功能的了解非常重要。该项目检验了雄激素（类固醇激素）通过与雄激素受体的相互作用在调节女性生殖生理学方面发挥主要作用的提议。我们已经开发了新的小鼠模型，我们将使用它来确定雄激素在调节女性生殖功能中的作用。