Androgen receptor mechanims in female reproductive physiology

澳大利亚每6对夫妇中就有1对发生不孕症，其中50%为女性，因此，加强我们对卵巢和子宫功能的了解是非常重要的。该项目测试了雄激素（类固醇激素）通过与雄激素受体的相互作用在调节女性生殖生理中起主要作用的提议。我们已经开发了新的小鼠模型，我们将用它来确定雄激素在调节女性生殖功能中的作用。

Infertility occurs in one in six Australian couples with 50% attributable to females, thus, enhancing our understanding of ovarian and uterine function is of great importance. This project tests the proposal that androgens (steroid hormones) play a major role in regulating female reproductive physiology through their interaction with the androgen receptor. We have developed novel mouse models which we will use to determine the roles of androgens in regulating female reproductive function.