The Sertoli cell: master regulator of hormone-induced spermatogenic development

该项目将确定主要激素(睾酮、卵泡刺激素、维生素A)在支持细胞中的关键作用。支持细胞是一种在睾丸中发现的独特的高度专业化的细胞，为精子产生提供必要的营养和结构支持。这项研究将为控制精子发育的生物途径提供新的理解，为不孕不育或癌症治疗或诊断带来新的分子靶点，或为男性提供新的避孕策略。

This project will determine the key roles of major hormones (testosterone, follicle-stimulating hormone, Vitamin A) in Sertoli cells, unique highly specialised cells found in the testis that provide essential nutritional and structural support for sperm production. This research will provide new understanding of the biological pathways controlling sperm development, leading to new molecular targets for infertility or cancer treatment or diagnosis, or new contraceptive strategies for men.