The role of arousal in the pathogenesis of obstructive sleep apnea and implications for novel therapeutic treatments

这项研究是旨在确定阻塞性睡眠呼吸暂停(OSA)各种生理原因(表型)的相对重要性的一系列研究的一部分，并有可能根据这些特征导致个性化定制的新疗法。具体地说，这项拟议的研究将调查睡眠唤醒(短暂唤醒)在阻塞性睡眠呼吸暂停综合征中的作用，并探索操纵唤醒阈值的方法，作为某些阻塞性睡眠呼吸暂停患者的一种新的治疗方法。

This research forms part of a series of studies aimed at characterizing the relative importance of the various physiological causes (phenotypes) of obstructive sleep apnea (OSA) and has the potential to lead to individually tailored novel therapies according to these traits. Specifically, this proposed research will investigate the role of arousal from sleep (brief awakening) in OSA and explore methods of manipulating the arousal threshold as a new treatment approach for certain OSA patients.