The role of sedatives and arousal in obstructive sleep apnoea – pathophysiology and therapeutic utility

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Recent studies indicate that certain sleeping pills (sedatives) may actually reduce obstructive sleep apnoea (OSA) severity in some patients. This research aims to determine the: 1) characteristics of patients who are most likely to respond to this novel approach. 2) effects of commonly prescribed sedatives on upper airway function and breathing during sleep. 3) utility for a sedative to yield sustained reductions in OSA severity and daytime sleepiness in the appropriately selected OSA patients.