The role of aspirin in the prevention of colorectal cancer

阿司匹林在预防结直肠癌中的作用

• 批准号: nhmrc : 1129811
• 负责人: A/Pr Robyn Woods
• 金额: $ 118.19万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-aspirin-prevention-colorectal-cancer/948472
• 关键词: role; aspirin; prevention; colorectal; cancer

ASPREE is a large, phase 3 clinical study of health participants over the age of 70 years who have been randomized to either continuous low dose aspirin or placebo for an average of 5 years. This grant is concerned with collecting long-term follow-up for an additional 5 years, especially for evidence of colorectal cancer (CRC) as well as the exploration of potential mechanisms of action by which aspirin may prevent the development of CRC.

ASPREE是一项大型的3期临床研究，对象为70岁以上的健康受试者，他们被随机分配接受连续低剂量阿司匹林或安慰剂治疗，平均为期5年。该补助金涉及收集额外5年的长期随访，特别是结肠直肠癌（CRC）的证据，以及探索阿司匹林可能预防CRC发展的潜在作用机制。