The role of cardiac muscle scar in cardiac muscle stiffness

胶原蛋白是疤痕的主要成分，在一些心脏中积累，我们可以预期这会增加僵硬，威胁心脏功能。我们已经在心脏磁共振成像（MRI）上显示心脏松弛不良与胶原蛋白增加相关。我们的目标是建立MRI结果和心脏僵硬度的直接测量之间的联系，僵硬度和胶原蛋白量之间的联系，以及抗纤维化治疗对心脏胶原蛋白的影响;辅助诊断，预后和结果。

Collagen, a major component of scar, accumulates in some hearts and we may expect this to increase stiffness, threatening heart function. We have shown poor heart relaxation correlates with increased collagen on heart magnetic resonance imaging (MRI). We aim to establish a link between MRI findings and direct measures of heart stiffness, a link between degree of stiffness and amount of collagen and effects of anti-fibrotic therapy on heart collagen; aiding diagnosis, prognosis and outcome.