The role of CD4+ T cells in the tumour killing by CD8+ memory T cells.

CD4 T 细胞在 CD8 记忆 T 细胞杀伤肿瘤中的作用。

• 批准号: nhmrc : 301084
• 负责人: Dr Germain Fernando
• 金额: $ 20.2万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-cd4-t-t-cells/80753
• 关键词: role; CD4+; cells; tumour; killing

It has been observed that human cancers grow in spite of the presence of tumour antigen specific memory CD8+ tumour killer T cells in the body. These memory killer cells are unable to kill the cancer. Our research work in a mouse model indicates that the CD8+ T cells can be activated to kill cancers if cancer antigen specific CD4+ T helper cells are activated. The mechanism how this happens is not clear. The role of regulatory or suppressor CD4+ T cells are also not known. In this proposal we wish to study the mechanism of how CD8+ memory T cells get activated to cancer killer cells by the CD4+ T helper cells. This information will help us to design better immunotherapies for cancer patients.

据观察，尽管体内存在肿瘤抗原特异性记忆CD8+肿瘤杀伤T细胞，但人类癌症仍会生长。这些记忆杀手细胞无法杀死癌细胞。我们在小鼠模型中的研究工作表明，如果激活癌症抗原特异性CD4+ T辅助细胞，CD8+ T细胞可以被激活来杀死癌症。这种情况发生的机制尚不清楚。调节或抑制CD4+ T细胞的作用也不清楚。在这个提议中，我们希望研究CD8+记忆T细胞如何被CD4+ T辅助细胞激活到癌症杀伤细胞的机制。这些信息将帮助我们为癌症患者设计更好的免疫疗法。