Needle free delivery of dengue and Zika vaccines to the skin

无针注射登革热和寨卡疫苗至皮肤

• 批准号: nhmrc : 1139754
• 负责人: Dr Germain Fernando
• 金额: $ 43.46万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Development Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/needle-free-delivery-vaccines-skin/1319077
• 关键词: Needle; free; delivery; dengue; Zika

There is no Zika vaccine and only one licensed dengue vaccine, which is age and region restricted because of poor efficacy. We have developed safe subunit vaccine candidates capable of inducing potent virus neutralizing antibodies and demonstrated protection from lethal dengue challenge in a mouse model. Here we are partnering with Vaxxas to undertake preclinical development and GLP toxicity trials for microarray patches delivering dengue and zika virus subunit vaccines.

没有寨卡疫苗，只有一种获得许可的登革热疫苗，由于疗效差，年龄和地区受到限制。我们已经开发了安全的亚单位疫苗候选物，能够诱导有效的病毒中和抗体，并在小鼠模型中证明了对致死性登革热攻击的保护作用。在这里，我们正在与Vaxxas合作，为提供登革热和寨卡病毒亚单位疫苗的微阵列贴片进行临床前开发和GLP毒性试验。