Nanopatch immunisation against pandemic influenza: improved immune responses at a reduced dose.

针对大流行性流感的纳米贴片免疫：以减少的剂量改善免疫反应。

• 批准号: nhmrc : 569726
• 负责人: Dr Germain Fernando
• 金额: $ 34.09万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/nanopatch-immunisation-pandemic-reduced-dose/95936
• 关键词: Nanopatch; immunisation; against; pandemic; influenza

Development of a new way to vaccinate against influenza that will make standard vaccines 100 times more potent than conventional syringe injection. The Nanopatch is made from a silicon wafer, bristling with micro-nanoscale spikes. It painlessly deposits vaccine under the skin surface. Experiments in mice show that even a small vaccine payload delivered to the skin generates good immune responses. The Nanopatch vaccination system is expected to be ready for clinical trials within a few years.

开发一种新的流感疫苗接种方法，使标准疫苗的效力比传统的注射器注射高100倍。纳米贴片由硅晶片制成，布满了微纳米级的尖刺。它无痛地将疫苗沉积在皮肤表面下。小鼠实验表明，即使是很小的疫苗有效载荷传递到皮肤产生良好的免疫反应。Nanopatch疫苗接种系统预计将在几年内准备好进行临床试验。