THE ROLE OF CHANGES IN THE HIPPOCAMPAL SEROTONIN TRANSPORTER IN THE PATHOLOGY OF SCHIZOPHRENIA

海马血清素转运蛋白的变化在精神分裂症病理学中的作用

• 批准号: nhmrc : 114253
• 负责人: Prof Brian Dean
• 金额: $ 22.69万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2000
• 资助国家: 澳大利亚
• 起止时间: 2000-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-changes-hippocampal-pathology-schizophrenia/77827
• 关键词: ROLE; CHANGES; HIPPOCAMPAL; SEROTONIN; TRANSPORTER

Schizophrenia is a serious mental illness that affects approximately 1% of the Australian population. The cause of the illness remains unknown but many lines of evidence suggest that changes in the function of a chemical neurotransmitter, serotonin, are involved in the disease process. We have shown a change in the serotonin transporter, a critical component of the brain which controls the actions of serotonin, in the an area of the brain called the hippocampus in subjects with schizophrenia. This proposal seeks to elucidate the mechanisms by which a change in the serotonin transporter may affect other important molecules in the hippocampus. In addition, we will continue our research designed to assess the usefulness of the 5,7-dihydroxytryptamine treated rat as a possible tool for the study of changes in the serotonin transporter.

精神分裂症是一种严重的精神疾病，影响大约1%的澳大利亚人口。疾病的原因尚不清楚，但许多证据表明，化学神经递质5-羟色胺的功能变化参与了疾病过程。我们已经显示了精神分裂症患者大脑中称为海马体的一个区域的5-羟色胺转运体的变化，5-羟色胺转运体是大脑的一个关键组成部分，控制着5-羟色胺的活动。这项提议试图阐明5-羟色胺转运体的变化可能影响海马体中其他重要分子的机制。此外，我们将继续我们的研究，旨在评估5，7-二羟色胺处理的大鼠作为研究5-羟色胺转运体变化的可能工具的有用性。