Mechanisms underlying changes in hippocampal information processing by neuromodulation (B12*)

神经调节导致海马信息处理发生变化的机制 (B12*)

• 批准号: 405644556
• 金额: --
• 依托单位: Forschungsgruppe Synthetische Biologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/405644556?language=en
• 关键词: Mechanisms; underlying; changes; hippocampal; information

Our project will scrutinise how serotonergic neuromodulation impacts hippocampal information processing. We will investigate to what extent serotonergic input controls excitation/inhibition balance within the hippocampus, in a state-dependent manner, and how this contributes to subcortical and hippocampal information processing. Serotonergic neuromodulation will be examined on several levels: behavioural experiments in conjunction with optogenetics will elucidate the impact of 5-HT on memory and sensory information processing, whereas electrophysiological recordings in combination with state-of-the-art imaging techniques will reveal the underlying mechanisms

我们的项目将仔细研究5-羟色胺能神经调节如何影响海马区的信息处理。我们将调查5-羟色胺能输入在多大程度上以状态依赖的方式控制海马区内的兴奋/抑制平衡，以及这如何有助于皮质下和海马区的信息处理。5-羟色胺能神经调节将在几个层面上进行研究：行为实验结合光遗传学将阐明5-羟色胺对记忆和感觉信息处理的影响，而电生理记录结合最先进的成像技术将揭示潜在的机制