Mechanisms underlying changes in hippocampal information processing by neuromodulation (B12*)

我们的项目将详细研究海马能神经调节如何影响海马信息处理。我们将研究在何种程度上，多巴胺能输入控制兴奋/抑制海马内的平衡，在一个状态依赖的方式，以及如何这有助于皮层下和海马的信息处理。5-羟色胺能神经调节将在几个层面上进行研究：行为实验结合光遗传学将阐明5-羟色胺对记忆和感觉信息处理的影响，而电生理记录结合最先进的成像技术将揭示潜在的机制

Our project will scrutinise how serotonergic neuromodulation impacts hippocampal information processing. We will investigate to what extent serotonergic input controls excitation/inhibition balance within the hippocampus, in a state-dependent manner, and how this contributes to subcortical and hippocampal information processing. Serotonergic neuromodulation will be examined on several levels: behavioural experiments in conjunction with optogenetics will elucidate the impact of 5-HT on memory and sensory information processing, whereas electrophysiological recordings in combination with state-of-the-art imaging techniques will reveal the underlying mechanisms