The role of clusterin in preventing atherosclerosis

凝聚素在预防动脉粥样硬化中的作用

• 批准号: nhmrc : 1012521
• 负责人: Dr Amy Wyatt
• 金额: $ 23.52万
• 依托单位: University of Wollongong
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-clusterin-preventing-atherosclerosis/109668
• 关键词: role; clusterin; preventing; atherosclerosis

In atherosclerosis, plaques are formed when damaged low density lipoprotein (LDL) and fibrinogen are deposited inside blood vessels. Clusterin is a protein that stabilises damaged clients in soluble complexes, thus preventing their deposition. This project will investigate the ability of clusterin to prevent the deposition of damaged LDL and fibrinogen. Elucidation of mechanisms for preventing protein deposition will identify novel therapeutic targets for the treatment of atherosclerosis.

在动脉粥样硬化中，当受损的低密度脂蛋白（LDL）和纤维蛋白原沉积在血管内时形成斑块。胆固醇是一种蛋白质，它可以稳定可溶性复合物中受损的客户，从而防止它们沉积。本项目将研究clusterin阻止受损LDL和纤维蛋白原沉积的能力。阐明预防蛋白质沉积的机制将为动脉粥样硬化的治疗确定新的治疗靶点。