The effect of hypochlorite on the toxicity and clearance of the Alzheimer’s disease-associated amyloid beta peptide

次氯酸盐对阿尔茨海默病相关淀粉样β肽的毒性和清除的影响

• 批准号: nhmrc : 1099991
• 负责人: Dr Amy Wyatt
• 金额: $ 31.76万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/effect-hypochlorite-toxicity-beta-peptide/662483
• 关键词: effect; hypochlorite; toxicity; clearance; Alzheimer

Alzheimer’s disease (AD) is the leading cause of dementia worldwide and a growing burden on our aging society. Recent studies support the idea that in AD a deleterious relationship exists between inflammation in the brain and the accumulation of amyloid beta (A?), a peptide with toxic properties. This proposal aims to examine the details of this relationship with a focus on the toxicity and clearance of A? when it is modified by hypochlortie, a chemical that is generated during inflammation.

阿尔茨海默病 (AD) 是全世界痴呆症的主要原因，也是老龄化社会日益沉重的负担。最近的研究支持这一观点，即在 AD 中，大脑炎症与β淀粉样蛋白（A？）（一种具有毒性的肽）的积累之间存在有害关系。该提案旨在研究这种关系的细节，重点关注 A? 的毒性和清除率。当它被次氯酸（炎症过程中产生的一种化学物质）修饰时。