The Role of Connexin40 in the Pathogenesis of Atrial Fibrillation Probed by Targeted In Vivo Gene Transfer

通过体内靶向基因转移探讨 Connexin40 在心房颤动发病机制中的作用

• 批准号: nhmrc : 503802
• 负责人: Dr Eddy Kizana
• 金额: $ 35.27万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-connexin40-pathogenesis-gene-transfer/99008
• 关键词: Role; Connexin40; Pathogenesis; Atrial; Fibrillation

Atrial fibrillation (AF) is a fast and irregular heart rhythm that can predispose sufferers to heart failure and stroke. AF occurs as the result of abnormal electrical conduction in the upper heart chambers. We have found that a protein called Cx40 causes abnormal conduction in heart cells when grown in culture. The aim of this research is to see if AF occurs when Cx40 is increased and prevented when Cx40 is decreased in an AF animal model, potentially defining Cx40 as new therapeutic target.

心房颤动 (AF) 是一种快速且不规则的心律，可能使患者容易患上心力衰竭和中风。房颤是由于上心室异常电传导引起的。我们发现，一种名为 Cx40 的蛋白质在培养时会导致心脏细胞传导异常。本研究的目的是观察在 AF 动物模型中，当 Cx40 增加时是否会发生 AF，而当 Cx40 减少时是否会预防 AF，从而有可能将 Cx40 定义为新的治疗靶点。